The tumor microenvironment harbors various immune cell types such as CD3+ T lymphocytes, CD4+ T helper cells (Th), cytotoxic T cells (CD8+), natural killer (NK) cells, and natural killer T (NKT) cells along with CD11b+ myeloid cell subsets including myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (9). This evidence concerns the gene CD4 and neoplasm.