The percentage of MDSCs in the blood was significantly increased (p < 0.05; Supplementary Figure 2P), while no changes were observed in macrophage populations in the blood and spleen upon CSD (Supplementary Figures 2M, N), indicating that MDSCs are the major subset of CD11b+ cells in the peripheral blood of tumor-bearing mice that were increased under this condition. This evidence concerns the gene ITGAM and neoplasm.