NLRP3 and mevalonic aciduria: Also, incubation of PBMCs from healthy controls with both the farnesyl pyrophosphate synthase inhibitor alendronate and LPS caused a marked increase in IL-1β release and mRNA expression levels of NLRP3. In addition, the expression of NLRP3 was found to be increased in PBMCs of 2 patients with MKD (76).