This indicates that the loss of prenylation of Rab GTPases in MKD does not lead to IL-1β release, whereas, in agreement with previous data (52), loss of prenylation of the GTPases that are prenylated by GGTase I, including Rho, Rac and Rap GTPases, does contribute to IL-1β release in MKD (67). The gene discussed is RAB6A; the disease is mevalonic aciduria.