This indicates that the loss of prenylation of Rab GTPases in MKD does not lead to IL-1β release, whereas, in agreement with previous data (52), loss of prenylation of the GTPases that are prenylated by GGTase I, including Rho, Rac and Rap GTPases, does contribute to IL-1β release in MKD (67). Here, IL1B is linked to mevalonic aciduria.