There is no doubt that combining the data concerning immunogenicity in MHCII (Aona-DRβ) genotyped monkeys with antigenicity in COVID-19 recovered patients regarding the different forms of the disease’s presentation and different ethnic HLA-DRβ1* genotyped groups will provide a very logical and rational methodology for a second generation of minimal subunit-based, chemically-synthesised peptides. Here, HLA-DRB1 is linked to COVID-19.