This approach cannot be informative, since performing assays with the complete 35-peptide mixture will not provide reliable information regarding individual peptides where each one should have been used for blastogenesis, IFNγ and multiple cytokine determination since cellular immune responses are so exquisite regarding aa sequence recognition, so much so that rotamer orientation of the 6 TCR contacting residues determines the immune response (as we have demonstrated with highly immunogenicity protection-inducing peptides against experimental infection with malaria) (22, 23). This evidence concerns the gene IFNG and infection.