The numbers of Th17 (CD4+IL-17+), TFH17 (CD4+CXCR5+IL-17+), and B17 (CD19+IL-17+) cells were lower in the salivary glands of RA-treated mice, whereas those of Treg (CD4+CD25+Foxp3+) cells were higher in the salivary glands of RA-treated mice (Figure 5D). This evidence concerns the gene FOXP3 and rheumatoid arthritis.