TREM2 and central nervous system cancer: Initially, Wang et al. found that, compared with noncancerous brain tissues, the expression level of TREM2 was significantly increase in glioma tissues, and the overexpression of TREM2 in human gliomas was closely associated with pathological grade and overall survival of patients, furthermore, silencing TREM2 could inhibit the proliferation, migration and invasion of glioma cells (79).