TREM2 and gastric cancer: Recently, Wang et al. revealed a novel role of TREM2 in mediating chemoresistance, they found that TREM2 was a potential target of microRNA-149 in gastric cancer, the overexpression of microRNA-149 could decrease the expression of TREM2 and further improve the 5-fluorouracil resistance through β-catenin signaling pathway (86).