Thus, together with loss of CCR7, SELL (lymph-node homing) and CLA (skin homing) the increased β7 integrin, ITGA4 and CXCR1 gene expression suggests a globally altered trafficking profile biased towards preferential gut homing, supporting potential clinical utility for the treatment of an autoimmune disorder of the gut. This evidence concerns the gene CCR7 and Autoimmunity.