The exact mechanism lncRNAs play in RA is still yet to be determined, however Yan et al. (2019) suggest lncRNA HIX003209 promotes a TLR4/NFκB proinflammatory phenotype in CD14+ infiltrating macrophages in RA by sponging miR−6089 (149). The gene discussed is NFKB1; the disease is rheumatoid arthritis.