In tumor, the expression level of chemokine CXCL9 and CXCL11 was significantly decreased in advanced stage CRC patients (stages IV, n = 11; p = 0.02 and p = 0.045; Figure 1F) compared to those in early stages (stages I, II and III, n = 18). This evidence concerns the gene CXCL9 and colorectal carcinoma.