Interestingly, IL-17F deficient mice, but not IL-17A deficient mice, were found to be resistant to chemically induced colitis and T cell induced colitis, with increased Treg population in colon, commensal dysbiosis (increased Clostridium cluster XIVa, reduced Prevotellaceae) and reduced expression of some antimicrobial peptides (78). This evidence concerns the gene IL17F and colitis.