GWAS showed that IL23R (rs11209026, rs1004819, rs10489629, rs11465804, rs1343151, rs10889677, rs11209032, rs1495965) and IL12B (rs6556416, rs10045431) single nuclear polymorphism (SNPs) are associated with the susceptibility to AS, as well as SpA related conditions, such as psoriasis and inflammatory bowel disease (IBD) (28–30). The gene discussed is IL12B; the disease is inflammatory bowel disease.