Casual effects of upregulated IL6-signaling have been found to be positively associated with RA (IVW mode effect=0.325, 95%CI 0.088 to 0.561, p=7.08E-03) and AS (IVW mode effect=1.240, 95%CI 0.495 to 1.980, p=1.1E-03). The gene discussed is IL6; the disease is rheumatoid arthritis.