As the results of MR present, the elevated concentration of sIL6R, which inhibits IL6-signaling, was negatively associated with the risk of RA (IVW mode effect=-0.020, 95%CI -0.0320 to -0.008, p=1.18E-03) and AS (IVW mode effect=-0.125, 95%CI -0.177 to -0.073, p=2.29E-06). The gene discussed is IL6R; the disease is rheumatoid arthritis.