Recipients with chronic GVHD induced by whole splenic T cells or by sorted donor CD8+ T cells both have lymphopenia, damage in the thymus, serum autoantibodies, and damage in small intestine, liver, lung, skin, and salivary and lacrimal glands, together with collagen deposition and fibrosis in target organ tissues (46, 47). The gene discussed is CD8A; the disease is chronic graft versus host disease.