Chronic GVHD with little acute GVHD can also be induced by naïve CD8+ T cells from C3H.SW (H-2Db, CD45.2) donor to MHC-matched B6/SJL (H-2Db, CD45.1) recipient (46, 56) or from C57BL/6 donor to MHC-mismatched BALB/c recipient models (46). The gene discussed is CD8A; the disease is chronic graft versus host disease.