CD1D and graft versus host disease: As one example, observations from murine models that NKT cells specific for nonpolymorphic CD1d suppressed acute GVHD (37) and preservation of NKT cells by conditioning regimens consisting of total lymphoid irradiation (TLI) and antithymocytes cell globulin (ATG) prevented GVHD while preserving GVL activity (38, 39) have been successfully translated into clinical application in humans (40, 41).