Overall, clinical symptoms and signs of AS patients were greatly relieved after 6 months of adalimumab therapy, along with improvements in C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), BASDAI, ASDAS, Bath Ankylosing Spondylitis Functional Index (BASFI), and Bath Ankylosing Spondylitis Metrology Index (BASMI), comparing with baseline values (all P values < 0.01, Table 1). The gene discussed is CRP; the disease is spondylitis.