Our observations demonstrated that the immune components of cluster 1 patients presented similar features to “immune inflamed tumor” such as the abundance of IL-12, MICB, NCAM1, NCAM2, and NKG2D while the second group (cluster 2) seemed to exhibit some of the “non-inflamed tumors” characteristics such as the expressions of TIM3, PDL1, IL-10, and TGF-β. The gene discussed is CD274; the disease is neoplasm.