Among the 23 chromosomes, chromosome 6 contained the largest number of DMPs (n = 51), among which 15 DMPs-annotated genes TRIM38, MAP3K5, ARG1, C6orf106, SRPK1, MAPK14, COL11A2, HLA-DRB1, HLA-DPB2, HLA-DQB1, HLA-C, C6orf10, BAT3, HLA-DPB1, and COL21A1 were definitely involved in autoimmunity in the literature. The gene discussed is HLA-DRB1; the disease is Autoimmunity.