When LGG tumors were stratified for PDGFD expression, patients with tumors enriched for the SPANK had a more favorable prognosis compared to LGG patients with a lower tumor abundance of SPANK (e.g. compare HPDGFD/HSPANK, red KM curve, to HPDGFD/LSPANK, grey KM curve and compare LPDGFD/HSPANK, yellow curve, to LPDGFD/LSPANK, blue curve) (Figure 4). The gene discussed is PDGFD; the disease is neoplasm.