Finally, high tumor expression of the NK cell receptor genes; KLRK1, KLRC1, KLRC2, KLRC3, and KLRC4 that encode the NKG2D, NKG2A, NKG2C, NKG2E and NKG2F, respectively, were all associated with improved prognosis and positively correlated with the SPANK and memory CD8+ T cell phenotypes, suggesting expression of these KLR NK cell receptor family gene products are important for LGG anti-tumor immunity in TCGA patient cohort. This evidence concerns the gene KLRC4 and neoplasm.