Given our results and those from other laboratories, it will be interesting to determine the expression of HLA-E in LGG and KLR family receptors on glioma-infiltrating NK cells and CD8+ T cells in different ethnic groups and to test whether blocking the inhibitory function of KLRC1 can enhance the anti-tumor activity of NK cells and CD8+ T cells in LGG and other brain cancers (102, 103). Here, HLA-E is linked to central nervous system cancer.