At the molecular level, Ju and colleagues have recently shown that hypoxia (1% O2) induces CSN8 (COP9 signalosome 8) expression, which correlates with several quiescence markers expression (i.e., NR2F1, DEC2, and p27KIP1), a decrease of MYC expression, and a lower level of ki67 in colorectal cancer cells (126). Here, COPS8 is linked to colorectal cancer.