TGFB1 and hepatocellular carcinoma: In a later study conducted by Liu et al. (85), Ang II was shown to upregulate AT1R and stimulate cell proliferation in HCC, by increasing proinflammatory cytokines and nicotinamide adenine dinucleotide phosphate oxidase activity, which increases Reactive Oxygen Species (ROS) level (86), while Qi et al. (87) found that Ang II promotes EMT, migration, and invasion through activation of the TGF-β signalling pathway in HCC (87).