MTOR and hepatocellular carcinoma: Telmisartan – another ARB – was found to reduce cell proliferation through activation of the AMP-activated protein kinase (AMPK) alongside inhibition of the mammalian Target of Rapamycin (mTOR) signalling pathways, which inhibit cell cycle regulatory proteins such as cyclin D1 and cyclin E, thus arresting the cell cycle in poorly differentiated HCC cells (89).