Shimizu et al. (95) confirmed the previous suggestion by investigating the effect of AT1R knockout in CRC mice models, where they found that liver metastasis was suppressed and TGF-β production was downregulated in KCs, thus indicating that liver metastasis is promoted by KCs, stimulating TGF-β production through AT1R signalling (95). The gene discussed is AGTR1; the disease is colorectal carcinoma.