Similarly, treating human U-118MG glioblastoma cells with the cytotoxic Bn analogue AN-215 reduced tumor size by 50%, decreased tumoral VEGF levels by 45%, and decreased the relative ratio of Bcl-2 to Bax proteins by 90%, indicating a net apoptotic gain and showing the effectiveness of the therapy (168). This evidence concerns the gene BAX and glioblastoma.