AKT1 and neuroblastoma: In nude mice (100) with SK-N-SH or BE(2)-C neuroblastoma cell xenografts, Bn administration increased the growth of the neuroblastoma cell xenografts, increased VEGF expression, increased expression of PECAM-1 (a marker for microvessels), and increased p-AKT in the xenografts, which were all attenuated by the addition of a GRPR antagonist.