In one study (143), 85% of the adult human glioblastoma cell lines (U-373MG, D-247MG, U-118MG, U-251MG, D-245MG, U-105MG, D-54MG, A-172MG, D-373MG) and pediatric glioblastoma cell lines (SJ-S6, SJ-G2) studied were reported to possess functional (increasing cytosolic [Ca2+]i) BnRs, and pharmacological studies demonstrated they were of the GRPR subtype. Here, GRPR is linked to glioblastoma.