PTEN and neuroblastoma: Silencing of GRP generation/release resulted in decreased anchorage-independent growth, inhibition of cell migration and neuroblastoma cell-mediated angiogenesis, inhibition of the activation of the of PTEN/AKT signaling cascade, deceased mRNA level of various oncogenes (MYCN, TWIST, FAK), and suppression of the development of metastases (202).