The silencing of AKT2 in cultured neuroblastoma cells resulted in decreased growth and decreased VEGF secretion in vitro, while Akt2-silenced xenografts in nude mice showed fewer liver metastases; therefore, Akt silencing caused the same results as knockout of GRPR in the neuroblastoma cells (190, 199). This evidence concerns the gene AKT2 and neuroblastoma.