In the human neuroblastoma cell line BE(2)-C, Bn stimulated secretion of VEGF (197), which was mediated by PKC activation and not by the Bn-induced activation of the Akt (increased pAKT) or ERK (increased p-ERK1/2) signaling cascades, which was also seen with Bn treatment. This evidence concerns the gene PRRT2 and neuroblastoma.