SP7 and skeletal dysplasia: With the recent advent of fast CRISPR/Cas9 protocols and in combination with the widely available transgenic reporter lines that drive fluorescent proteins under control of cell-type specific promoters (such as sp7(osx):GFP [osteoblasts] and col2a1a:mCherry [chondrocytes]), it is feasible to rapidly test gene function related to skeletal dysplasias or early mineralization defects in zebrafish larvae (77, 81, 82) (Figure 3).