On the other hand, IL-1β regulates sleep by acting on monoaminergic neurotransmission (Imeri and Opp, 2009) and specific neuronal receptors (Davis et al., 2015), and the disruption of the circadian rhythmicity of brain homeostatic mechanisms and inflammatory signaling has been proposed as a pathogenetic mechanism in mood disorders, which involve a marked disruption of all circadian mechanisms (Wirz-Justice and Benedetti, 2019). Here, IL1B is linked to mood disorder.