ELAC2 and hypertrophic cardiomyopathy: For example, the R781H substitution in RNase ZL/ELAC2, which has been linked with prostate cancer and hypertrophic cardiomyopathy, mainly affects mt-tRNA processing while has no major differences on the nuclear pre-tRNA processing (Minagawa et al., 2005; Saoura et al., 2019).