FBN1 and Insulin resistance: There was also an increased level of circulating asprosin in fasting state, both in adults and children with insulin resistance (Romere et al., 2016; Wang C.Y. et al., 2019; Wang M. et al., 2019), in people with T2DM (Wang Y. et al., 2018), and in women with polycystic ovary syndrome (Alan et al., 2019).