• A highly expressed in a variety of neoplasm and promotes EMT and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling (Han et al., 2019) • Involves in regulating DNA synthesis in S phase and chromatin maintenance in mitosis, and maintains cell growth in a nuclear transport-independent way (Wei and Yang, 2019). The gene discussed is AKT1; the disease is hepatocellular carcinoma.