SREBF1 and metabolic dysfunction-associated steatohepatitis: In addition, according to a study on patients with simple steatosis and NASH, downregulation of SREBP-1c may be associated with the development of burned-out NASH through decreasing quantification of SREBP-1c positive hepatocyte nuclei and increasing mature SREBP-1c levels by immunoblot analysis (Nagaya et al., 2010).