PLAT and Hepatic fibrosis: The molecules, including Scd1, Acta2, collagen type I alpha 1 chain (Col1a1), Timp1, Foxm1, Sult1e1, and plasminogen activator (Plat), are also involved in hepatotoxicity pathways, such as liver fibrosis, liver hyperplasia/hyperproliferation, liver proliferation, and liver necrosis/cell death (Table 9).