Liver-specific Phb1 homozygous KO (referred to as Phb1−/−) mouse showed positive staining for OV-6, an oval cell marker, and glutathione S-transferase Pi (GST Pi), a preneoplastic marker, at 3 weeks old and exhibited spontaneous liver injury, fibrosis, and hepatocellular carcinoma (HCC) from 8 months of age (Ko et al., 2010). The gene discussed is HPGDS; the disease is hepatocellular carcinoma.