PLIN1 and obesity due to melanocortin 4 receptor deficiency: In addition, a haplotype of two SNPs of the PLIN1 gene, 13041A>G (rs2304795) and 14995A>T (rs1052700), has previously been associated with obesity risk (Qi et al., 2004) and with response to a 6-month endurance exercise intervention (Jenkins et al., 2010).