Moreover, consistent with the lipid-reducing effect in previous reports via HFD induced hyperlipidemia rats (Jin et al., 2010), or HFD and streptozotocin induced Type 2 diabetic rats (Zhang et al., 2014), HLJDD still reduced serum TG, LDL, and CHOL in high-fat diet feeding ApoE−/− mice, and the lipid-reducing effects of HLJDD were in a dose-dependent manner. Here, APOE is linked to hyperlipidemia.