Search terms included “IL-38” combined with “autoimmune diseases” or “inflammation” or “systemic lupus erythematosus (SLE)” or “RA” or “psoriasis” or “inflammatory bowel disease (IBD)” or “autoimmune thyroid disease (AITD)” or “multiple sclerosis (MS)” or “primary Sjogren’s syndrome (pSS)” or “Behcet’s disease (BD)” or “genome editing.” Particularly, this reviewpaid attention on that IL-38 may regulate autoimmune diseases by regulating immune responses, which will help to understand IL-38 and provide an abundant basis for clinical treatment and drug research. This evidence concerns the gene IL1F10 and Sjogren syndrome.