AGEs increase IL-6 and intercellular adhesion molecule-1 (ICAM-1) expression via the RAGE, MAPK, and nuclear factor-κB (NF-κB) pathways in human gingival fibroblasts and exacerbate the progression of the pathogenesis of periodontal diseases (Nonaka et al., 2018). This evidence concerns the gene ICAM1 and periodontal disorder.