IL6 and diabetes mellitus: Increased the ratio of RANKL/OPG and the secretion of AGEs, reactive oxygen species (ROS), TNF-α, IL-1β, and IL-6 in diabetes enhance periodontal ligament (PDL) and osteoblast apoptosis, induces osteoclastogenesis, and reduces bone formation (Pacios et al., 2013; Wu et al., 2015).