However, we found that the expression of p-GSK-3β was different from the results of previous studies (Gupte et al., 2018), which may be related to the time stage after myocardial infarction (Lal et al., 2014) or likely related different MI areas, such as MI and non-MI areas or maybe lcz696 likely regulating β-catenin and GSK-3β through two independent pathways, this will encourage us to explore further. This evidence concerns the gene GSK3B and myocardial infarction.