SFRP1 and myocardial infarction: Barandon et al. established an acute MI model using transgenic mice overexpressing sFRP-1 and reported the inhibition of the Wnt pathway after acute MI in mice as well as the consequent reduction in the MI area and rate of heart rupture; thus, sFRP-1 could control the healing process after MI (Alfaro et al., 2010).