Luteolin is a secondary plant metabolite that belongs to flavonoids and is widely distributed in honeysuckle, Perilla, pepper and other herbs and vegetables, mainly in the form of glycosides in plants; luteolin inhibits epithelial-mesenchymal transition (EMT) and matrix metalloproteinase (MMP) secretion likely through deactivation of STAT3 signaling, to directly reduce the phosphorylation level of STAT3 in cancerous cells of pancreas, and inhibits IL-6 to reduce the invasion of pancreatic cancer cells (Huang et al., 2015). The gene discussed is STAT3; the disease is pancreatic neoplasm.