STAT3 and ulcerative colitis: As natural products, hesperidin and TAHP possess extensive pharmacological properties, such as neuroprotective, and anti-inflammatory properties, inhibit the secretion of TNF-α and IL-6 and reduce the phosphorylation of NF-κB; hesperidin in combination with cinnamaldehyde significantly decreased p-JAK2 and p-STAT3 and significantly increased the expression of SOCS3 protein in ulcerative colitis (Elhennawy et al., 2021).