GK mediates the dephosphorylation of STAT3 in Tyr705 and prevents it from entering the nucleus, thereby inhibiting STAT3-mediated gene expression, such as antiapoptotic Bcl-XL protein, thereby inhibiting the proliferation of prostate cancer DU-145 cells (Jeon et al., 2015). The gene discussed is STAT3; the disease is prostate carcinoma.