PTPN2 and neoplasm: Wedelolactone significantly prolonged the duration of STAT1 tyrosine phosphorylation and prolonged the IFN-γ-induced STAT1 phosphorylation by inhibiting the T-cell protein tyrosine phosphatase (TCPTP)-dependent dephosphorylation of STAT1 and synergized with IFN-γ in inducing cell death among certain STAT1 expressing tumor cells (Chen et al., 2013) (Table 2).