Rats with acne induced by oleic acid had significantly up-regulated pathways, such as IL-17 signaling pathway, glycolysis/gluconeogenesis, galactose metabolism, gap junction, histidine metabolism, spinocerebellar ataxia, protein digestion and absorption, estrogen signaling pathway, biosynthesis of unsaturated fatty acids metabolism, glycerophospholipid metabolism and linoleic acid metabolism. Here, IL17A is linked to cerebellar ataxia.