Rats with acne induced by oleic acid had significantly up-regulated pathways, such as IL-17 signaling pathway, glycolysis/gluconeogenesis, galactose metabolism, gap junction, histidine metabolism, spinocerebellar ataxia, protein digestion and absorption, estrogen signaling pathway, biosynthesis of unsaturated fatty acids metabolism, glycerophospholipid metabolism and linoleic acid metabolism. The gene discussed is IL17A; the disease is acne.