The animal model of kidney injury was treated with DZHSP and found that DZHSP inhibits reactive oxygen species (ROS) and kidney injury molecule-1 (KIM-1), reduces the expression of TNF-α, MCP-1, MIP-2 inflammatory factors, inhibits inflammatory cells chemotaxis and activation, reduce the level of selectin expression, inhibit oxidative stress, reduce lipid peroxidation and free radical damage, thereby reducing renal ischemia-reperfusion injury (Jia et al., 2011; Zhao et al., 2019). The gene discussed is HAVCR1; the disease is kidney injury.