In addition, scutellarin up-regulates the expression of Nrf2 and promotes the expression of HO-1, SOD, CAT in the kidney, which may inhibit the oxidative damage of the kidney through the Nrf2/HO-1 signaling pathway and improve diabetic nephropathy (Liu T. et al., 2018; Mei et al., 2019; Gao et al., 2020). This evidence concerns the gene HMOX1 and diabetic kidney disease.