It can also be found in diabetic nephropathy models that DZHSP can reduce renal fibrosis and tubular damage, improve the expression of fibrosis markers of diabetic nephropathy, reduce proteinuria and serum creatinine, and phosphorylate PKCβII/Akt/JNK1/2/p38 signaling pathway Inhibit renal fibrosis (Jiang et al., 2016). This evidence concerns the gene AKT1 and renal fibrosis.