DZXXI can reduce the urinary microalbumin excretion rate (UAER), increase SOD and GSH-Px activities, inhibit reactive oxygen species production and membrane lipid peroxidation, remove reactive oxygen species, increase tissue antioxidant enzyme activities, decrease ROS production through MAPK and JAK-STAT channels, reduce the thickening of the basement membrane of the diabetic glomerulus and the proliferation of the mesangial matrix, and delay glomerular sclerosis (Chen, 2009; Cheng et al., 2007). Here, SOD1 is linked to Glomerular sclerosis.