TNF and cerebrovascular disorder: Pharmacological experimental studies have shown that in the MCAO rat model, scutellarin inhibits the release of TNF-α, IL-1β and other inflammatory factors, reduces the expression of MMP-9, Caspase 3, increases the expression of anti-apoptotic factor Bcl-2, and prevents Extracellular matrix damage and blood-brain barrier destruction, inhibit cell inflammation and apoptosis, promote the recovery of nerve function, and improve cerebrovascular diseases (Wang L. Z. et al., 2006; Yang et al., 2019a; Chen et al., 2020).