DZHSI can inhibit the increase in bronchial wall thickness and collagen fiber thickness in COPD model rats, reduce MMP-9, TGF-and Smad3 mRNA levels in lung tissue in COPD rats, raise Smad7 mRNA levels and improve fibrosis in lung tissue, thus delaying or improving the disease progression of COPD airway remodeling (Du et al., 2017). The gene discussed is SMAD3; the disease is chronic obstructive pulmonary disease.