CASP3 and cancer: Scutellarin can inhibit the proliferation, migration and invasion of renal cancer cells (ACHN, 786-O) in a dose-dependent manner in vivo and in vitro, and induce their apoptosis, and significantly reduce cyclin D1 (cyclin D1) and cyclin-dependent kinases (CDK1), Bcl-2, MMP-2, MMP-9 and other key protein expression, enhance the expression of Bax, cleaved Caspase-3 and p21, induce cancer cell apoptosis, and also increase PTEN by inhibiting the P13K/AKT/mTOR pathway, partially inhibit the proliferation and invasion of renal cell carcinoma (Deng et al., 2018).