It should be emphasized that relatively few rhesus monkeys live beyond ∼25 years, which is prior to the age at which they begin to show significant hippocampal tauopathy (Paspalas et al., 2018; Datta et al., 2021); thus, the systematic study of p-tau induction will be critically important in further developing the macaque AD model. The gene discussed is MAPT; the disease is Alzheimer disease.