Tau phosphorylation at Ser404 occurs more frequently after TBI than in neurodegenerative diseases such as AD, in which the phosphorylation sites at Thr205, Thr181, Ser262, and Tyr396 are much more common (Katsumoto et al., 2019; Barthelemy et al., 2020). The gene discussed is MAPT; the disease is Alzheimer disease.