Recent evidence indicates that the activation of the nucleotide-binding oligomerization domain-like receptor pyrin domain-containing protein 3 inflammasome is one of the most important factors for the release of high mobility group box-1 and is widely involved in cognitive dysfunction in patients with AD and animal models (Singhal et al., 2014; Pennisi et al., 2017; Thawkar and Kaur, 2019). The gene discussed is HMGB1; the disease is Alzheimer disease.