NEFL and nervous system disorder: This model was tested due to the suggestion that NfL could potentially be a useful biomarker of neural damage (Alirezaei et al., 2020), particularly in certain clinical populations such as individuals with neurological disorders (Gaetani et al., 2019), and if this were the case, the use of NfL as a clinical blood-derived biomarker would have significantly fewer logistical and financial barriers than MRI scans and may be more accessible for both research and clinical purposes.