The hemodynamic condition could induce inflammation filtration and vessel remodeling in the vascular wall (Albarran-Juarez et al., 2018; Lu et al., 2019; Zhang et al., 2020), which would cause atherosclerosis, IA growth/rupture, etc. Recent studies reported that oscillator flow could induce the inflammation in the vascular wall and inhibit the expression of vascular protective factors (Albarran-Juarez et al., 2018) (e.g., endothelial nitric oxide synthase). This evidence concerns the gene NOS3 and atherosclerosis.