Acute and chronic sleep loss induces glucose intolerance and insulin resistance; decrease insulin-like growth factor (IGF)-1 and adiponectin levels (Van Leeuwen et al., 2010; Broussard et al., 2015, 2016); and induce dyslipidemia and systemic low-grade inflammation (Gangwisch et al., 2010; Broussard et al., 2015) in non-obese subjects (humans and animal models). The gene discussed is IGF1; the disease is Insulin resistance.