INSR and Glucose intolerance: This hypothesis is supported by the fact that insulin receptor (IR), and IGF-1 receptor (IGF1R) specific knock-outs in the hippocampus and in the amygdala not only decrease the expression of AMPA receptors, but also develop into glucose intolerance, anxiety-like behaviors and impaired memory recognition, and spatial memory (Soto et al., 2019).