For a given CT38 concentration, the hemodynamic effects were greater in ME/CFS patients than in healthy subjects, and this differential diminished with increasing concentration, e.g., CT38 Cmax of 0.3 and 0.8 ng/ml result in mean HR increases in patients that are, respectively, 1.8× and 1.6× the corresponding change in healthy subjects (Figures 4A–D). Here, FTHL17 is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.