FN1 and fibrosis: Fibrosis, which is defined as fibroblasts excessively depositing extracellular matrix (ECM) mainly composed of collagen (COL), fibronectin (FN), and laminin (LN), is a common reaction to injury and inflammation in the central nervous system (CNS) and peripheral organs (Bataller and Brenner, 2005; Lee and Kalluri, 2010; Travers et al., 2016; Lederer and Martinez, 2018; Mack, 2018; Dorrier et al., 2021).