GFAP and Alzheimer disease: Moreover, a recent single cell analysis of non-neuronal cell populations in the 5xFAD transgenic mouse model of AD revealed a transient astrocyte response as the disease progresses, from a GFAP-low state to a GFAP-high state, as well as an AD-specific population termed “disease-associated astrocytes” (Habib et al., 2020).