MAPT and Alzheimer disease: Moreover, exercise is thought to be of benefit as a treatment for AD due to its capacity to stimulate the release of neurotrophic factors (Prado Lima et al., 2018), decreasing deposition of amyloid-β plaques (Prado Lima et al., 2018), and improving tau pathology (Belarbi et al., 2011; Fleeman and Proctor, 2021).