TARDBP and proteostasis deficiencies: In cultured oligodendrocytes, oxidative insult induces stress granules, membrane-less organelles that transiently store translationally silenced mRNA, including Mbp (Wang et al., 2010), and are thought to act as nucleation events for inclusion body formation in TDP-43/FUS-proteinopathies upon aberrant dynamics of assembly and disassembly (Baradaran-Heravi et al., 2020).