Moreover, in the plasma of sALS patients, both TDP-43 and FUS can be detected in microvesicles (Sproviero et al., 2018), and the accumulation of TDP-43 in plasma exosomes is currently under investigation as a potential progression biomarker in ALS (Chen et al., 2020). The gene discussed is FUS; the disease is amyotrophic lateral sclerosis.