A higher proportion of sALS (Supplementary Figure 3B) and C9orf72 ALS (Supplementary Figure 3C) cases had aggregations of CAII mRNA transcripts compared to control cases (Supplementary Figure 3A) but this did not reach statistical significance (p = 0.17; Supplementary Figure 3D). Here, CA2 is linked to amyotrophic lateral sclerosis.