MBP and amyotrophic lateral sclerosis: Quantification showed an increased number of oligodendrocytes with seven or more MBP mRNA transcripts in C9orf72 ALS patients compared to controls (p = 0.043; Figure 1D) as well as an overall increase in the number of oligodendrocytes with aggregations of MBP mRNAs (whereby more than half the nucleus was occupied by MBP transcripts; Figure 1E) compared to controls (p = 0.013).