In the well characterized SOD1G93A mouse model of ALS, one study found decreased numbers of mature oligodendrocytes, increased oligodendrocyte precursors as well as lower MBP and CNPase protein levels yet also showed a lower g-ratio (which corresponds to thicker myelin sheaths) and no quantifiable difference in LFB staining of the lumbar spinal cord (Kang et al., 2013). The gene discussed is CNP; the disease is amyotrophic lateral sclerosis.