This aligns with studies that identified insulin receptors at hippocampal glutamatergic synapses, suggesting a role of insulin in neurotransmission, synaptic plasticity, and modulation of learning and memory, while its inhibition is described in Alzheimer’s disease and related animal models (Bomfim et al., 2012). The gene discussed is INSR; the disease is early-onset autosomal dominant Alzheimer disease.