Purinergic signaling is involved in cancer cell proliferation (Di Virgilio and Adinolfi, 2017), and both P2 (Di Virgilio et al., 2018) and P1 (Allard D. et al., 2017) receptors as well as CD39 and CD73 enzymes (Allard B. et al., 2017) could be new targets in cancer. The gene discussed is NT5E; the disease is cancer.