Hypermethylation of DLX6-AS137,38 (cg22421859, chr7:96622043 on hg19), the most significant classifier of these groups (cutoff: 0.4, Supplementary Fig. 21), demonstrated a high significance of 5-year EFS (p = 0.0001) and identified patients with a poor predicted prognosis, including HB cases of infant (p < 0.0001) or those with the positive annotation factor except for M (p = 0.0232) (Fig. 7c). This evidence concerns the gene DLX6 and hemoglobin measurement.