Consistent with prior results, most HBs in this study were characterized by frequently mutated genes, CTNNB1 and TERT. While somatic mutation/deletion of CTNNB1 exon 3 was observed in more than 80% of HB patients younger than 8-years of age, promoter mutation of TERT was mostly seen in the tween HB cases, which suggests two distinct pathways of these childhood hepatic malignancies. The gene discussed is CTNNB1; the disease is hemoglobin measurement.