Moreover, PRKCA has been suggested as a positional candidate for the shared genetic predisposition to asthma and obesity [75], and in utero exposure to polycyclic aromatic hydrocarbons from both ambient sources and MSDP has been previously reported as a risk factor for both asthma and obesity in early life [76]. Here, PRKCA is linked to obesity due to melanocortin 4 receptor deficiency.