IFNL3 and infection: Interestingly, as a causal variant for natural clearance of infection with HCV infection, variant rs4803217 is located near the three classical ARE motifs and on the MRE motifs of two myomiRs in the IFNL3 3′-UTR, and strongly influences both ARE motif-mediated 3′-UTR activity, and miRNA regulation of 3′-UTR activity [31].