In a landmark publication, Braak stages of tau pathology were proposed by Braak H and Braak E to illustrate how Alzheimer’s disease-related tau began in the transentorhinal cortex, then extended to the inferior and lateral temporal cortices, to the posterior cingulate cortex, and widely spread in isocortical cerebral areas in end-stage disease [2]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.