The anti-metastatic ZNF507 knockdown effect was checked by protein EMT markers expression; elevated E-cadherin and decreased N-cadherin, Vimentin, Snail, and Slug in both DU145 and 22Rv1 cells, indicating ZNF507 may affect the growth, proliferation, and metastatic properties of PC cells (Fig. 2M, Fig.S3E). This evidence concerns the gene CDH2 and pachyonychia congenita.