The anti-metastatic ZNF507 knockdown effect was checked by protein EMT markers expression; elevated E-cadherin and decreased N-cadherin, Vimentin, Snail, and Slug in both DU145 and 22Rv1 cells, indicating ZNF507 may affect the growth, proliferation, and metastatic properties of PC cells (Fig. 2M, Fig.S3E). The gene discussed is VIM; the disease is pachyonychia congenita.