NSCLC research indicated that circ_PIP5K1A facilitated carcinogenesis and development by regulating different miRNA/mRNA axes, including miR-600/HIF-1α, miR-142-5p/insulin-like growth factor-1 (IGF-1) and miR-136-5p/B-cell lymphoma-2 (Bcl-2) [8–10]. This evidence concerns the gene IGF1 and non-small cell lung carcinoma.