Interestingly, the NDFIP2 level was found to be significantly reduced in 371 HCC tissue, compared with 50 normal liver tissues by matching the expression levels of NDFIP2 in the TCGA database (https://portal.gdc.cancer.gov/), and low NDFIP2 expression was found to imply a poor prognosis of HCC based on the Kaplan–Meier Plotter database (http://kmplot.com/) (Fig. 4B, C). The gene discussed is NDFIP2; the disease is hepatocellular carcinoma.